He won this award for the first time in 2002 for Best Actor (Mejor Actor).Two years later he was honored with this award for Best Supporting Actor (Mejor Actor de Reparto).Rodrigo participated in the film "The 33" based on a real-life event happened in Chile, when a gold and copper mine collapsed trapping 33 miners underground for 69 days.The movie was filmed in a mine in Colombia and in the city of Copiapo, the specific place in the north of Chile where this event occurred.Santoro also provided the voice for the main character in Stuart little and its sequel in the Brazilian dubbed copies.His first major role in a movie production came in 2001, with Bicho de Sete Cabeças (Brainstorm) by Brazilian director Laís Bodansky.
He is an actor and has appeared in several stage shows, movies and TV series.
He starred the role of Paulo in an American television drama series Lost in 2006.
Edit Brazilian beauty Mel Fronckowiak is his love partner. They are having romantic love affairs as a boyfriend and girlfriend since 2013.
Santoro went on to play parts in many of Globo's projects, such as Olho no Olho (1993), Pátria Minha (1994), Explode Coração (1995), O Amor Está no Ar (1997), Suave Veneno (1999) and Mulheres Apaixonadas (2003).
He as well as played in the role of a priest in miniseries Hilda Furacão (1998).