Wilson thinks that Amber breaks his pattern of going for needy women. However, House agrees to tests for endometriosis as well. He figures she's lying and has another gambit to get hired. He thinks that she's just trying to get back at him. She tells him that he has three mutually incompatible guesses and he has to guess whether she's trying to get back at him or just trying to be with Wilson. When Kutner brings up Taub's choice to give up his plastic surgery practice to work as a fellow, Taub admits that people don't change on a whim. They try to treat her for porphyria and have to admit they think her current religious beliefs are a symptom. Cuddy argues changing lifestyles is a good idea if you don't like your life.
Foreman and Taub go to do an environmental scan and Taub says, although he's Jewish, he doesn't respect orthodox traditions like arranged weddings. Meanwhile, the patient has developed respiratory arrest, showing Cuddy's diagnosis is wrong.
They talk to her and she admits having used heroin and living a wild lifestyle before she converted to Hasidic Judaism six months previously. The team thinks it is Wegener's disease, but House rejects it because he still thinks the conversion is a symptom. House orders a stress test despite the risk of a heart attack. She invites House to join them and goes to get a table. House then realizes to his horror that Wilson likes Amber because Amber is just like House. The husband starts to worry that treatment will change her back to the person she was before she converted.
On the romance front, House confronts Wilson about his new relationship with the “Cuttthroat Bitch” and plots to break them up.
At a traditional Hasidic wedding ceremony, the bride starts to feel ill, then realizes she is bleeding on her dress. Meanwhile, at Princeton-Plainsboro, House is challenging Wilson's decision to date Amber.
They test the patient's central nervous system by seeing if she sweats appropriately under stress.
The husband doesn't want to be there because he might see her without her clothes on. They realize the patient had hypothermia even though she was in a warm room. The patient is bleeding internally, but they can't find the source. He admits that this won't cure her if they find the bleed, but it will keep her alive.