Apart from his career in acting, he has also ventured into businesses.As reported, soon Ackles along with his family members will be opening a brewery, Family Business Brewing Co., in Dripping Springs.It owns the title of the longest-running North American sci-fi series in history.In the summer of 2007, Ackles took on the role of Priestly in the independent comedy Ten Inch Hero.
In 2005, Ackles joined the cast of the WB show horror/drama series Supernatural where he stars as Dean Winchester.
The film began hitting the film festival circuit in early 2007 and Ackles received high praise for his comedic timing in the role.
In February 2009, the film was released on DVD exclusively by Blockbuster Home Video.
He also starred as the lead in the box office success My Bloody Valentine 3D and portrayed Jason Todd in the popular animated film Batman: Under the Red Hood.
Ackles currently stars as Dean Winchester on the CW series Supernatural. Ackles had planned to study sports medicine at Texas Tech University and to become a physical therapist, but instead moved to Los Angeles to start his acting career.