Tenofovir disoproxil fumarate requires initial diester hydrolysis for conversion to tenofovir and subsequent phosphorylations by cellular enzymes to form tenofovir diphosphate.
Tenofovir diphosphate inhibits the activity of HIV-1 RT by competing with the natural substrate deoxyadenosine 5'-triphosphate and, after incorporation into DNA, by DNA chain termination.
It has a molecular formula of C Emtricitabine is a white to off-white crystalline powder with a solubility of approximately 112 mg/m L in water at 25 °C.
EMTRIVA is the brand name for emtricitabine, a synthetic nucleoside analog of cytidine.
Tenofovir disoproxil fumarate (VIREAD, also known as tenofovir DF) is converted in vivo to tenofovir, an acyclic nucleoside phosphonate (nucleotide) analog of adenosine 5'-monophosphate.
Genotypic analysis of these isolates identified the M184I/V and/or K65R amino acid substitutions in the viral RT.
Emtricitabine: Emtricitabine-resistant isolates of HIV have been selected in vitro.